Neuropathic pain of peripheral origin
@article{Galer1995NeuropathicPO, title={Neuropathic pain of peripheral origin}, author={Bradley S Galer}, journal={Neurology}, year={1995}, volume={45}, pages={S17 - S25} }
A variety of mechanisms may generate pain resulting from injury to the peripheral nervous system.None of these mechanisms is disease-specific, and several different pain mechanisms may be simultaneously present in any one patient, independent of diagnosis. Diagnosis of neuropathic pain is often easily made from information gathered on neurologic examination and from patient history. Evidence of sensory disturbances elicited on examination combined with laboratory tests confirming injury to…
177 Citations
Treatment of painful peripheral neuropathy.
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Neuropathic pain management remains challenging because of heterogeneous responses between individuals and the fact that pain relief is rarely complete, however, monotherapy with a well-chosen agent or rational polypharmacy that combines medications with different mechanisms of action will benefit a majority of patients with neuropathic pain.
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Pharmacotherapy is the mainstay of neuropathic pain management, with the majority of clinical data supporting the use of three main drug classes: tricyclic antidepressants; (1) anticonvulsants; and (3) anesthetic-antiarrhythmics.
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Topical medications offer a distinct advantage over systemic administration for those orofacial disorders that are regional, near the surface and chronic and that demonstrate some response such as pain relief to topical or subcutaneous anesthetics.
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The introduction in the therapeutical armamentarium of antiepileptic drugs and the results derived from clinical studies indicate that some of these compounds show promise in the treatment of neuropathic pain.
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