Neuropathic pain

@article{Treede2008NeuropathicP,
  title={Neuropathic pain},
  author={R. Treede and T. Jensen and J. Campbell and G. Cruccu and J. Dostrovsky and J. Griffin and P. Hansson and R. Hughes and T. Nurmikko and J. Serra},
  journal={Neurology},
  year={2008},
  volume={70},
  pages={1630 - 1635}
}
Pain usually results from activation of nociceptive afferents by actually or potentially tissue-damaging stimuli. Pain may also arise by activity generated within the nervous system without adequate stimulation of its peripheral sensory endings. For this type of pain, the International Association for the Study of Pain introduced the term neuropathic pain, defined as “pain initiated or caused by a primary lesion or dysfunction in the nervous system.” While this definition has been useful in… Expand
Neuropathic pain: Peripheral and central mechanisms
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These peripheral and central sensitization phenomena in neuropathic pain represent the pathophysiological reason for the beneficial effect of antihyperalgesic treatment in this type of pain. Expand
Evaluation of Predictors for Persistent Pain Post-total Knee Replacement
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This review focuses on the current understanding, clinical assessment and pharmalogical management of neuropathic pain. Expand
Neuropathic pain: a clinical perspective.
  • R. Baron
  • Medicine
  • Handbook of experimental pharmacology
  • 2009
TLDR
A new hypothetical concept was proposed in which pain is analyzed on the basis of underlying mechanisms and the increased knowledge of pain-generating mechanisms and their translation into symptoms and signs may in the future allow a dissection of the mechanisms that operate in each patient. Expand
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A broad range of disease and injury can result in neuropathic pain and there are multiple classification schema ranging from anatomic to etiologic; none are as of yet universally accepted. Expand
Neuropathic pain: From mechanisms to treatment.
TLDR
Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a common chronic pain condition with major impact on quality of life and the major classes of therapeutics include drugs acting on α2 δsubunits of calcium channels, sodium channels, and descending modulatory inhibitory pathways. Expand
Screening and Measurement Tools for Neuropathic Pain: Their Role in Clinical Research and Practice
TLDR
Recently, several screening and measurement tools have been developed to discriminate the nociceptive and neuropathic pain. Expand
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TLDR
Because of the considerable overlap between neuropathic and nociceptive pain in terms of mechanisms and treatment modalities, it might be more constructive to view these entities as different points on the same continuum. Expand
Etiology and Pharmacology of Neuropathic Pain
TLDR
It is suggested that drugs that affect multiple processes, rather than a single specific target, show the greatest promise for future therapeutic development. Expand
Unilateral peripheral neuropathic pain: The role of neurodiagnostic skin biopsy.
TLDR
NSB has the important property of being used to investigate the skin, allowing obtaining a diagnosis of small fiber axonal neuropathy of peripheral nerves supplying every body part covered by skin, and allows going beyond the possibilities of neurophysiological tests which are available only for a limited number of peripheral nerve endings. Expand
Spontaneous pain is reduced by conditioning pain modulation in peripheral neuropathy but not in fibromyalgia—Implications for different pain mechanisms
  • E. Kosek
  • Medicine
  • Scandinavian journal of pain
  • 2012
The International Association for the Study of Pain (IASP) has ecently redefined neuropathic pain as “pain caused by a lesion r disease of the somatosensory system’, thereby excluding condiions withExpand
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TLDR
Neuropathic pain is almost always characterised by changes in sensibility, usually involving the thin-fibre system (peripheral nerve fibres or central projections) and special emphasis is put on the examination of sensory dysfunction. Expand
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Attempts have been made for more than two decades to identify verbal descriptors idiosyncratic for neuropathic pain, including the Leeds assessment of neuropathic symptoms and signs (LANSS), with the intention of identifying ‘patients in whom neuropathic Pain Syndrome is under diagnosed’. Expand
Neuropathic pain: clinical characteristics and diagnostic workup
TLDR
The diagnosis of peripheral or central neuropathic pain should be made only when the history and signs are indicative of neuropathy in conjunction with neuroanatomically correlated pain distribution and sensory abnormalities within the area of pain. Expand
Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4)
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The 10‐item questionnaire developed in the present study constitutes a new diagnostic instrument, which might be helpful both in clinical research and daily practice and found that a relatively small number of items are sufficient to discriminate neuropathic pain. Expand
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TLDR
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Assessment of neuropathic pain
TLDR
The clinical presentation of pain can vary widely between individuals despite the same underlying aetiology, and common features of neuropathic pain include spontaneous and evoked pains. Expand
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TLDR
Distinction between neuropathic and inflammatory pain mechanisms is suggested, as well as the distinction between Neuropathic pain from hypersensitivity pain disorders, previously termed neuropathic pain due to neurological dysfunction. Expand
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