Neuropathic pain

@article{Treede2008NeuropathicP,
  title={Neuropathic pain},
  author={RD. Treede and Troels Staehelin Jensen and J. N. Campbell and Giorgio Cruccu and Jonathan O. Dostrovsky and John Wesley Griffin and Per T. Hansson and Robert Hughes and Turo Nurmikko and Jordi Serra},
  journal={Neurology},
  year={2008},
  volume={70},
  pages={1630 - 1635}
}
Pain usually results from activation of nociceptive afferents by actually or potentially tissue-damaging stimuli. Pain may also arise by activity generated within the nervous system without adequate stimulation of its peripheral sensory endings. For this type of pain, the International Association for the Study of Pain introduced the term neuropathic pain, defined as “pain initiated or caused by a primary lesion or dysfunction in the nervous system.” While this definition has been useful in… 

Neuropathic Pain and Chronic Opioid Use

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Recently, several screening and measurement tools have been developed to discriminate the nociceptive and neuropathic pain.

Etiology and Pharmacology of Neuropathic Pain

It is suggested that drugs that affect multiple processes, rather than a single specific target, show the greatest promise for future therapeutic development.

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Because of the considerable overlap between neuropathic and nociceptive pain in terms of mechanisms and treatment modalities, it might be more constructive to view these entities as different points on the same continuum.

Neuropathic pain: Spotlighting anatomy, experimental models, mechanisms, and therapeutic aspects

The determination of common molecular markers with suitable in vitro models would simplify the assessment of neuropathic pain in vivo and provide insights into common molecular mechanisms of the disease and establish a basis to search for satisfying therapeutic approaches.

Understanding and Treating Neuropathic Pain

It is suggested that targeting ion channels in the sensory nerves and excitatory transmission in the dorsal horn may lead to urgently needed new treatments for neuropathic pain and the effectiveness of gabapentinoids may be increased by combining these agents with the TRPV1 agonist capsaicin.

Central Pain States

Targeting of peripherally expressed pain-related molecules in injury- induced chronic neuropathic pain.

  • T. HiraiA. Hama
  • Biology, Medicine
    CNS & neurological disorders drug targets
  • 2014
Examining pain-related molecules in the pathogenesis of peripheral nerve injury-induced pain and discusses potentially useful therapeutic targets on the basis of preclinical findings in rodent neuropathic pain models focuses on transmembrane proteins, particularly the voltage-gated and ligand- gated ion channels, which modulate peripheral nerve function.
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References

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Neuropathic pain is almost always characterised by changes in sensibility, usually involving the thin-fibre system (peripheral nerve fibres or central projections) and special emphasis is put on the examination of sensory dysfunction.

Neuropathic pain: clinical characteristics and diagnostic workup

The diagnosis of peripheral or central neuropathic pain should be made only when the history and signs are indicative of neuropathy in conjunction with neuroanatomically correlated pain distribution and sensory abnormalities within the area of pain.

Assessment of neuropathic pain

The clinical presentation of pain can vary widely between individuals despite the same underlying aetiology, and common features of neuropathic pain include spontaneous and evoked pains.

Defining Neuropathic Pain

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  • Medicine, Psychology
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Distinction between neuropathic and inflammatory pain mechanisms is suggested, as well as the distinction between Neuropathic pain from hypersensitivity pain disorders, previously termed neuropathic pain due to neurological dysfunction.

EFNS guidelines on neuropathic pain assessment

This review led to the development of guidelines to be used in the management of patients with neuropathic pain, and the simplest psychometric scales and quality of life measures are probably the best methods.