Neuropathic and chronic pain stimuli downregulate central mu-opioid and dopaminergic transmission.

@article{Niikura2010NeuropathicAC,
  title={Neuropathic and chronic pain stimuli downregulate central mu-opioid and dopaminergic transmission.},
  author={Keiichi Niikura and Minoru Narita and Eduardo Roque Butelman and Mary Jeanne Kreek and Tsutomu Suzuki},
  journal={Trends in pharmacological sciences},
  year={2010},
  volume={31 7},
  pages={299-305}
}
Although morphine and other mu-opioid agonists are the main analgesics for severe pain, these compounds have potential for abuse and/or addiction. This has complicated the use of mu-agonists in the treatment of chronic pain. However, clinical studies show that when mu-agonist analgesics are appropriately used to control pain, actual abuse or addiction does not usually occur, although some risk factors that increase vulnerability need to be considered, including genetic variation. We review… CONTINUE READING

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