Neurooncology of familial cancer syndromes.

  title={Neurooncology of familial cancer syndromes.},
  author={Andreas F. Hottinger and Yasmin N Khakoo},
  journal={Journal of child neurology},
  volume={24 12},
The majority of tumors of the nervous system are sporadic. However, a subset of patients with tumors and their families are predisposed to developing cancers of the central nervous system and other organs because of a germline mutation. In the last decade, many of the genes responsible for these typically autosomal dominant familial tumor syndromes have been identified. Additionally, our understanding of the mechanisms of carcinogenesis in these syndromes has increased, allowing for more… CONTINUE READING
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