Neurons produce type I interferon during viral encephalitis.

  title={Neurons produce type I interferon during viral encephalitis.},
  author={Sophie Delhaye and Sophie T. Paul and Gjon Blakqori and Muriel Minet and Friedemann Weber and Peter Staeheli and Thomas Michiels},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 20},
Type I interferons, also referred to as IFN-alpha/beta, form the first line of defense against viral infections. Major IFN-alpha/beta producers in the periphery are the plasmacytoid dendritic cells (pDCs). Constitutive expression of the IFN regulatory factor (IRF)-7 enables pDCs to rapidly synthesize large amounts of IFN-alpha/beta after viral infection. In the central nervous system (CNS), pDCs are considered to be absent from the parenchyma, and little is known about the cells producing IFN… CONTINUE READING


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