Neurons express hemoglobin alpha- and beta-chains in rat and human brains.

@article{Richter2009NeuronsEH,
  title={Neurons express hemoglobin alpha- and beta-chains in rat and human brains.},
  author={Franziska Richter and Bernhard H. Meurers and Chunni Zhu and Vera P Medvedeva and M F Chesselet},
  journal={The Journal of comparative neurology},
  year={2009},
  volume={515 5},
  pages={538-47}
}
Hemoglobin is the oxygen carrier in vertebrate blood erythrocytes. Here we report that hemoglobin chains are expressed in mammalian brain neurons and are regulated by a mitochondrial toxin. Transcriptome analyses of laser-capture microdissected nigral dopaminergic neurons in rats and striatal neurons in mice revealed the presence of hemoglobin alpha, adult chain 2 (Hba-a2) and hemoglobin beta (Hbb) transcripts, whereas other erythroid markers were not detected. Quantitative reverse… CONTINUE READING