Neurons exclusively express N-Bak, a BH3 domain-only Bak isoform that promotes neuronal apoptosis.

Abstract

Bak is generally recognized as a multidomain, pro-apoptotic member of the Bcl-2 family. Bak and Bax are functionally redundant in non-neuronal cells and represent a mitochondrial convergence point for cell death signaling pathways. This functional redundancy, however, may not exist in neurons in which the single deletion of Bax is sufficient to confer… (More)

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Cite this paper

@article{Uo2005NeuronsEE, title={Neurons exclusively express N-Bak, a BH3 domain-only Bak isoform that promotes neuronal apoptosis.}, author={Takuma Uo and Yoshito Kinoshita and Richard J S Morrison}, journal={The Journal of biological chemistry}, year={2005}, volume={280 10}, pages={9065-73} }