• Biology, Medicine
  • Published in
    Acta neurobiologiae…
    2006

Neurons derived from PC12 cells have the potential to develop synapses with primary neurons from rat cortex.

@article{Zhou2006NeuronsDF,
  title={Neurons derived from PC12 cells have the potential to develop synapses with primary neurons from rat cortex.},
  author={Tao Zhou and Bainan Xu and Haiping Que and Qiuxia Lin and Shuanghong Lv and Shaojun Liu},
  journal={Acta neurobiologiae experimentalis},
  year={2006},
  volume={66 2},
  pages={
          105-12
        }
}
Neuron transplantation is considered to be a promising therapeutic method to replace functions lost due to central nervous system (CNS) damage. However, little is known about the extent to which implanted neuron-like cells can develop into mature neurons and acquire essential properties, and especially formation of synapses with host neurons. In this investigation we seeded PC12 cells labeled with GFP into primary cultured neurons isolated from rat cerebral cortex to build a co-culture system… CONTINUE READING

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Neurites from PC12 cells are connected to each other by synapse-like structures.

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