Neurons depend on astrocytes in a coculture system for protection from glutamate toxicity.

@article{Brown1999NeuronsDO,
  title={Neurons depend on astrocytes in a coculture system for protection from glutamate toxicity.},
  author={David R Brown},
  journal={Molecular and cellular neurosciences},
  year={1999},
  volume={13 5},
  pages={379-89}
}
  • David R Brown
  • Published 1999 in Molecular and cellular neurosciences
Glutamate can be toxic to neurons although it is a neurotransmitter. Regulation of extracellular glutamate levels is essential for prevention of glutamate neurotoxicity. Astrocytes play a major role in clearance of glutamate released by neurons. A coculture system combining cerebellar cells and astrocytes was employed to investigate the astrocytic control of glutamate toxicity. Coculture of astrocytes with cerebellar neurons enhanced uptake of glutamate by astrocytes. Inhibition of glutamate… CONTINUE READING