Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis.

@article{Haubensak2004NeuronsAI,
  title={Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis.},
  author={Wulf Haubensak and Alessio Attardo and Winfried Denk and Wieland B Huttner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 9},
  pages={3196-201}
}
Neurons of the mammalian CNS are thought to originate from progenitors dividing at the apical surface of the neuroepithelium. Here we use mouse embryos expressing GFP from the Tis21 locus, a gene expressed throughout the neural tube in most, if not all, neuron-generating progenitors, to specifically reveal the cell divisions that produce CNS neurons. In addition to the apical, asymmetric divisions of neuroepithelial (NE) cells that generate another NE cell and a neuron, we find, from the onset… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-4 of 4 references

Development (Cambridge, U.K

V. Tarabykin, A. Stoykova, N. Usman, P. Gruss
2001

Results and Problems in Cell Differentiation

V. S. Caviness, T. Takahashi, R. S. Nowakowski
Mouse Brain Development, • 2000

Developmental Neurobiology (Plenum, New York)

M. Jacobson
1991
View 2 Excerpts

Neocortical Development (Raven, New York)

S. A. Bayer, J. Altman
1991
View 2 Excerpts

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