Neuronal targeting in diabetes mellitus: a story of sensory neurons and motor neurons.

@article{Zochodne2008NeuronalTI,
  title={Neuronal targeting in diabetes mellitus: a story of sensory neurons and motor neurons.},
  author={Douglas W Zochodne and Noor Ramji and Cory A. Toth},
  journal={The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  year={2008},
  volume={14 4},
  pages={311-8}
}
Diabetes mellitus targets the peripheral nervous system in unique but disabling ways. Although several mechanisms may target peripheral neurons, they render a degenerative pattern of damage that begins in distal terminals. Moreover, sensory neurons are involved early, motor neurons later. By studying a variety of diabetic neuropathy models in rats, mice, and other species, an overall appreciation of its neurodegeneration emerges. Understanding how mechanisms of diabetes complications target… CONTINUE READING
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