Neuronal survival and dynamics of ultrastructural damage after dendrotomy in low calcium.

@article{Lucas1990NeuronalSA,
  title={Neuronal survival and dynamics of ultrastructural damage after dendrotomy in low calcium.},
  author={Jeffrey H. Lucas and Dennis G. Emery and Michael L. Higgins and Guenter W. Gross},
  journal={Journal of neurotrauma},
  year={1990},
  volume={7 3},
  pages={169-92}
}
To determine the contributions of calcium to development of ultrastructural damage and neuronal death after mechanical injury, we amputated primary dendrites from over 300 cultured mammalian spinal neurons under normal (1.8 mM) or low (less than or equal to 30 microM) calcium conditions. Two general categories of early ultrastructural change were seen in both normal and low calcium: (1) a lesion-dependent gradient of damage that moved centripetally through the proximal segment and penetrated… CONTINUE READING

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