Neuronal survival: Early dependence on Schwann cells

@article{Davies1998NeuronalSE,
  title={Neuronal survival: Early dependence on Schwann cells},
  author={Alun M. Davies},
  journal={Current Biology},
  year={1998},
  volume={8},
  pages={R15-R18}
}
  • A. Davies
  • Published 1 January 1998
  • Biology
  • Current Biology
View on Elsevier
doi.org
50 Citations
Background Citations
16
Methods Citations
1
Results Citations
2

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50 Citations

Integrin receptors are required for cell survival and proliferation during development of the peripheral glial lineage.
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It is concluded that integrins can complement growth factors in the control of glial cell numbers and play a role in survival during cell migration.
The Neurobiology of Schwann Cells
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The reciprocal signalling between peripheral glial cells and neurons in development and adult life revealed in recent years is highlighted, and the profound change in survival regulation from neuron‐dependent Schwann cell precursors to adult Schwann cells that depend on autocrine survival signals is discussed.
Schwann cell development in embryonic mouse nerves
TLDR
In the mouse, the transition from precursors to Schwann cells takes place 2 days earlier than in the rat, and is accompanied by the appearance of the O4 antigen and the establishment of an autocrine survival circuit.
Promotion of periostin expression contributes to the migration of Schwann cells
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It is demonstrated that the expression of periostin is stimulated by the ErbB ligand NRG1 and influences the migration of Schwann cell precursors, which is particularly high in migratory Schwann cells.
Glial but not neuronal development in the cochleo‐vestibular ganglion requires Sox10
J. Neurochem. (2010) 114, 1827–1839.
SpL201: A conditionally immortalized Schwann cell precursor line that generates myelin
TLDR
The SpL201 cell line is conditionally immortalized rat Schwann cell precursor cells using a retrovirally encoded EGFR/neu fusion protein and expresses p75 and nestin, two proteins expressed by neural crest‐derived cells, as well as peripheral myelin protein 22, protein zero, and Oct‐6 as markers of the Schwanncell lineage.
Developmental regulation in the Schwann cell lineage.
TLDR
The main developmental stages in the Schwann cell lineage have now been identified and the cells start to differentiate, first along the myelin pathway, with mature non-myelinating cells appearing later.
Glial control of neuronal development.
  • G. Lemke
  • Biology
    Annual review of neuroscience
  • 2001
Reciprocal interactions between differentiating glial cells and neurons define the course of nervous system development even before the point at which these two cell types become definitively…
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