Neuronal survival: Early dependence on Schwann cells

@article{Davies1998NeuronalSE,
  title={Neuronal survival: Early dependence on Schwann cells},
  author={Alun M. Davies},
  journal={Current Biology},
  year={1998},
  volume={8},
  pages={R15-R18}
}
  • A. Davies
  • Published 1 January 1998
  • Biology
  • Current Biology

Figures from this paper

Integrin receptors are required for cell survival and proliferation during development of the peripheral glial lineage.
TLDR
It is concluded that integrins can complement growth factors in the control of glial cell numbers and play a role in survival during cell migration.
The Neurobiology of Schwann Cells
TLDR
The reciprocal signalling between peripheral glial cells and neurons in development and adult life revealed in recent years is highlighted, and the profound change in survival regulation from neuron‐dependent Schwann cell precursors to adult Schwann cells that depend on autocrine survival signals is discussed.
Schwann cell development in embryonic mouse nerves
TLDR
In the mouse, the transition from precursors to Schwann cells takes place 2 days earlier than in the rat, and is accompanied by the appearance of the O4 antigen and the establishment of an autocrine survival circuit.
Promotion of periostin expression contributes to the migration of Schwann cells
TLDR
It is demonstrated that the expression of periostin is stimulated by the ErbB ligand NRG1 and influences the migration of Schwann cell precursors, which is particularly high in migratory Schwann cells.
Glial but not neuronal development in the cochleo‐vestibular ganglion requires Sox10
J. Neurochem. (2010) 114, 1827–1839.
SpL201: A conditionally immortalized Schwann cell precursor line that generates myelin
TLDR
The SpL201 cell line is conditionally immortalized rat Schwann cell precursor cells using a retrovirally encoded EGFR/neu fusion protein and expresses p75 and nestin, two proteins expressed by neural crest‐derived cells, as well as peripheral myelin protein 22, protein zero, and Oct‐6 as markers of the Schwanncell lineage.
Developmental regulation in the Schwann cell lineage.
TLDR
The main developmental stages in the Schwann cell lineage have now been identified and the cells start to differentiate, first along the myelin pathway, with mature non-myelinating cells appearing later.
Glial control of neuronal development.
  • G. Lemke
  • Biology
    Annual review of neuroscience
  • 2001
Reciprocal interactions between differentiating glial cells and neurons define the course of nervous system development even before the point at which these two cell types become definitively
...
...

References

SHOWING 1-10 OF 17 REFERENCES
Severe neuropathies in mice with targeted mutations in the ErbB3 receptor
TLDR
It is shown that sensory and motor neurons require factors for their survival that are provided by developing Schwann cells, and that ErbB3 functions in a cell-autonomous way during the development of SchwANN cells, but not in the survival of sensory or motor neurons.
Disruption of the CNTF gene results in motor neuron degeneration
TLDR
It is reported that abolition of CNTF gene expression by homologous recombination results in a progressive atrophy and loss of motor neurons in adult mice, which is functionally reflected by a small but significant reduction in muscle strength.
Neurotrophin switching: where does it stand?
  • A. Davies
  • Biology
    Current Opinion in Neurobiology
  • 1997
Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
TLDR
It is demonstrated that ErbB4 is an essential in vivo regulator of both cardiac muscle differentiation and axon guidance in the central nervous system (CNS) and differences in the hindbrain phenotypes of these mutants are consistent with the action of a new Erb B4 ligand in the CNS.
Multiple essential functions of neuregulin in development
TLDR
It is shown that neUREgulin -/ - embryos die during embryogenesis and display heart malformations, and the phenotype demonstrates that in vivo neuregulin acts locally and frequently in a paracrine manner.
Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development.
TLDR
It is shown that elimination of the Ig-like domain-containing neuregulins by homologous recombination results in embryonic lethality associated with a deficiency of ventricular myocardial trabeculation and impairment of cranial ganglion development, and concludes that IgL-domain- containing neureGulins play a major role in cardiac and neuronal development.
Neuregulins and neuregulin receptors in neural development
Requirement for neuregulin receptor erbB2 in neural and cardiac development
TLDR
The results demonstrate the importance of erbB2 in neural and cardiac development and find that mutant embryos die before Ell, probably as a result of dysfunctions associated with a lack of cardiac trabeculae.
...
...