Neuronal substrates of complex behaviors in C. elegans.

@article{deBono2005NeuronalSO,
  title={Neuronal substrates of complex behaviors in C. elegans.},
  author={Mario de Bono and Andres Villu Maricq},
  journal={Annual review of neuroscience},
  year={2005},
  volume={28},
  pages={
          451-501
        }
}
A current challenge in neuroscience is to bridge the gaps between genes, proteins, neurons, neural circuits, and behavior in a single animal model. The nematode Caenorhabditis elegans has unique features that facilitate this synthesis. Its nervous system includes exactly 302 neurons, and their pattern of synaptic connectivity is known. With only five olfactory neurons, C. elegans can dynamically respond to dozens of attractive and repellent odors. Thermosensory neurons enable the nematode to… 
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References

SHOWING 1-10 OF 241 REFERENCES
Signal transduction in the Caenorhabditis elegans nervous system.
TLDR
A molecular model for touch sensation has emerged from studies of the mechanosensory response; the receptors and signal transduction mechanisms in olfactory neurons are being elucidated; and an unusual neuroendocrine role for a TGF-beta-related peptide in chemosensORY neurons has been discovered.
Functional mapping of neurons that control locomotory behavior in Caenorhabditis elegans.
TLDR
It is found that the AIY neuron class serves to tonically modulate reversal frequency of animals in various sensory environments via the repression of the activity of a bistable switch composed of defined command interneurons.
Neuronal Control of Locomotion in C. elegans Is Modified by a Dominant Mutation in the GLR-1 Ionotropic Glutamate Receptor
The C. elegans Glutamate Receptor Subunit NMR-1 Is Required for Slow NMDA-Activated Currents that Regulate Reversal Frequency during Locomotion
TLDR
It is proposed that NMDA receptors in C. elegans provide long-lived currents that modulate the frequency of movement reversals during foraging behavior and can rescue the nmr-1 mutant phenotype.
A Putative Cyclic Nucleotide–Gated Channel Is Required for Sensory Development and Function in C. elegans
Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans
TLDR
In the nematode Caenorhabditis elegans, a D1‐like dopamine receptor gene (dop‐1) modulates the plasticity of mechanosensory behaviors in which dopamine had not been implicated previously, providing genetic evidence that dopamine signaling modulates behavioral plasticity in C. elegans.
C. elegans Locomotory Rate Is Modulated by the Environment through a Dopaminergic Pathway and by Experience through a Serotonergic Pathway
Negative Regulation and Gain Control of Sensory Neurons by the C. elegans Calcineurin TAX-6
Modulation of serotonin-controlled behaviors by Go in Caenorhabditis elegans
TLDR
Results demonstrate that the level of Go activity is a critical determinant of several C. elegans behaviors and suggest that Go mediates many of the behavioral effects of 5-HT.
Differential Expression of Glutamate Receptor Subunits in the Nervous System of Caenorhabditis elegans and Their Regulation by the Homeodomain Protein UNC-42
TLDR
It is shown that expression of these subunits in this circuit is differentially regulated by the homeodomain protein UNC-42 and that UNC- 42 is also required for axonal pathfinding of neurons in the circuit.
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