Neuronal specification in the spinal cord: inductive signals and transcriptional codes

  title={Neuronal specification in the spinal cord: inductive signals and transcriptional codes},
  author={Thomas M. Jessell},
  journal={Nature Reviews Genetics},
  • T. Jessell
  • Published 1 October 2000
  • Biology
  • Nature Reviews Genetics
Neural circuits are assembled with remarkable precision during embryonic development, and the selectivity inherent in their formation helps to define the behavioural repertoire of the mature organism. In the vertebrate central nervous system, this developmental program begins with the differentiation of distinct classes of neurons from progenitor cells located at defined positions within the neural tube. The mechanisms that specify the identity of neural cells have been examined in many regions… 

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Strategies for the generation of neuronal diversity in the developing central nervous system

  • SK McConnell
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
This article focuses on three strategies employed by the CNS to generate distinct classes of neuronal phenotypes during development: dorsal-ventral polarization in the spinal cord, segmentation in the hindbrain, and a lamination in the cerebral cortex.

The specification of dorsal cell fates in the vertebrate central nervous system.

The cellular interactions and molecular mechanisms that direct neuronal cell fates in the dorsal half of the vertebrate central nervous system are discussed.

Regulation of vertebrate neural cell fate by transcription factors

The role of Sonic hedgehog in neural tube patterning

The evidence that Shh does impose ventral identity on cells in the neural tube is discussed, the role of a graded Shh signal in patterning the neural tubes is focused on, and the interaction of Shh with other factors that affect its signalling outcome is discussed.

Conservation of neurogenic genes and mechanisms

Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system.

It is found that the floor plate throughout the midbrain, hindbrain and spinal cord does not form in Gli2 homozygotes, suggesting that early signals derived from the notochord can be sufficient for establishing the basic d/v domains of cell differentiation in the ventral spinal cord and hindbrain.