Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction

@inproceedings{Cannon2012NeuronalST,
  title={Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction},
  author={Ashley Cannon and Baoli Yang and Joshua A. Knight and Ian M. Farnham and Yongjie Zhang and Charles A. Wuertzer and Simon D’Alton and Wen-lang Lin and Monica Castanedes-Casey and Linda Rousseau and Brittany Scott and Michael Jurasic and John M. Howard and Xin Yu and Rachel M. Bailey and Matthew R. Sarkisian and Dennis W. Dickson and Leonard Petrucelli and Jada Lewis},
  booktitle={Acta Neuropathologica},
  year={2012}
}
Ubiquitin-immunoreactive neuronal inclusions composed of TAR DNA binding protein of 43 kDa (TDP-43) are a major pathological feature of frontotemporal lobar degeneration (FTLD-TDP). In vivo studies with TDP-43 knockout mice have suggested that TDP-43 plays a critical, although undefined role in development. In the current report, we generated transgenic mice that conditionally express wild-type human TDP-43 (hTDP-43) in the forebrain and established a paradigm to examine the sensitivity of… CONTINUE READING

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