Neuronal properties of a thyroid C-cell line: partial repression by dexamethasone and retinoic acid.

@article{Russo1992NeuronalPO,
  title={Neuronal properties of a thyroid C-cell line: partial repression by dexamethasone and retinoic acid.},
  author={Andrew F Russo and Thomas M. Lanigan and Bridget Sullivan},
  journal={Molecular endocrinology},
  year={1992},
  volume={6 2},
  pages={
          207-18
        }
}
We have analyzed the effect of extracellular stimuli on the differentiation state of the CA77 thyroid C-cell line as a model to understand the control of neural crest cell differentiation. In contrast to the endocrine C-cell phenotype, we found that CA77 cells have a neuronal phenotype characterized by laminin-induced neurites, neuronal antigens, and calcitonin gene-related peptide (CGRP) mRNA expression. Treatment with dexamethasone and retinoic acid reversibly repressed some of these neuronal… CONTINUE READING
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