Neuronal production of lipocalin-2 as a help-me signal for glial activation.

Abstract

BACKGROUND AND PURPOSE We explored the hypothesis that injured neurons release lipocalin-2 as a help me signal. METHODS In vivo lipocalin-2 responses were assessed in rat focal cerebral ischemia and human stroke brain samples using a combination of ELISA and immunostaining. In vitro, microglia and astrocytes were exposed to lipocalin-2, and various… (More)
DOI: 10.1161/STROKEAHA.114.005733

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