Neuronal number, volume, and apoptosis of the left dentate gyrus of chronically stressed pigs correlate negatively with basal saliva cortisol levels.

@article{Beek2004NeuronalNV,
  title={Neuronal number, volume, and apoptosis of the left dentate gyrus of chronically stressed pigs correlate negatively with basal saliva cortisol levels.},
  author={Eline M. van der Beek and Victor Marius Wiegant and Willem G. P. Schouten and Frank J C M van Eerdenburg and Leanne W.S. Loijens and Carianne van der Plas and Marjan A Benning and Hester de Vries and E. Ron de Kloet and Paul John Lucassen},
  journal={Hippocampus},
  year={2004},
  volume={14 6},
  pages={688-700}
}
Although the consequences of stress and hypercortisolemia for the rodent hippocampal dentate gyrus (DG) are well known, little is known about other species. For pigs, tethered housing represents a well-established chronic stressor that shares many similarities with restraint paradigms, as evidenced by profound changes in behavior and autonomic and endocrine dysfunction, including flattened cortisol rhythms and hypercortisolemia--all conditions that may threaten hippocampal viability in rat… CONTINUE READING