Neuronal nitric oxide synthase and calmodulin-dependent protein kinase IIalpha undergo neurotoxin-induced proteolysis.

@article{Hajimohammadreza1997NeuronalNO,
  title={Neuronal nitric oxide synthase and calmodulin-dependent protein kinase IIalpha undergo neurotoxin-induced proteolysis.},
  author={Iradj Hajimohammadreza and Kadee J. Raser and Rathna Nath and Ram Gopal Nadimpalli and Mary E Scott and Kenneth Kezhi Wang},
  journal={Journal of neurochemistry},
  year={1997},
  volume={69 3},
  pages={1006-13}
}
Calpain (calcium-activated neutral protease) has been implicated as playing a role of neuronal injury in cerebral ischemia and excitotoxicity. Here we report that, in addition to extreme excitotoxic conditions [N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and kainate challenges], other neurotoxins such as maitotoxin, A23187, and okadaic acid also induce calpain activation, as detected by m-calpain autolytic fragmentation and nonerythroid alpha… CONTINUE READING

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