Neuronal nitric oxide synthase: prototype for pulsed enzymology.

  title={Neuronal nitric oxide synthase: prototype for pulsed enzymology.},
  author={John C. Salerno},
  journal={FEBS letters},
  volume={582 10},
The established paradigm in understanding and describing enzyme activity uses formalisms based on steady-state assumptions, including Michaelis-Menten and King-Altman approaches. These are appropriate for enzymes operating under steady-state conditions. Signal generating enzymes transfer information, rather than material. Because the information capacity of a signal channel depends on frequency, steady-state descriptions may not be appropriate. Recently, Stuehr and coworkers described a novel… CONTINUE READING

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