Neuronal nicotinic receptors: from structure to pathology

@article{Gotti2004NeuronalNR,
  title={Neuronal nicotinic receptors: from structure to pathology},
  author={C. Gotti and F. Clementi},
  journal={Progress in Neurobiology},
  year={2004},
  volume={74},
  pages={363-396}
}
Neuronal nicotinic receptors (NAChRs) form a heterogeneous family of ion channels that are differently expressed in many regions of the central nervous system (CNS) and peripheral nervous system. These different receptor subtypes, which have characteristic pharmacological and biophysical properties, have a pentameric structure consisting of the homomeric or heteromeric combination of 12 different subunits (alpha2-alpha10, beta2-beta4). By responding to the endogenous neurotransmitter… Expand
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