Neuronal nicotinic receptor beta2 and beta4 subunits confer large differences in agonist binding affinity.

@article{Parker1998NeuronalNR,
  title={Neuronal nicotinic receptor beta2 and beta4 subunits confer large differences in agonist binding affinity.},
  author={Michael J Parker and Andreas Beck and Charles W Luetje},
  journal={Molecular pharmacology},
  year={1998},
  volume={54 6},
  pages={1132-9}
}
We used equilibrium binding analysis to characterize the agonist binding properties of six different rat neuronal nicotinic receptor subunit combinations expressed in Xenopus laevis oocytes. The alpha4beta2 receptor bound [3H]cytisine with a Kdapp of 0.74 +/- 0. 14 nM. The rank order of Kiapp values of additional nicotinic ligands, determined in competition assays, was cytisine < nicotine < acetylcholine < carbachol < curare. These pharmacological properties of alpha4beta2 expressed in oocytes… CONTINUE READING
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Rat a3/b4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: pharmacology of ligand binding and function

  • Y Xiao, A Meyer EL Thompson JM Surin, J Wroblewski, KJ Kellar
  • Mol Pharmacol
  • 1998
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