Neuronal nicotinic receptor antagonist reduces anxiety-like behavior in mice

@article{Roni2011NeuronalNR,
  title={Neuronal nicotinic receptor antagonist reduces anxiety-like behavior in mice},
  author={Monzurul Amin Roni and Shafiqur Rahman},
  journal={Neuroscience Letters},
  year={2011},
  volume={504},
  pages={237-241}
}
Brain cholinergic neurotransmission has been implicated in the modulation of anxiety in humans and evidence suggests that drugs targeting neuronal nicotinic acetylcholine receptor (nAChR) could have potential for the treatment of anxiety. The objective of present study was to examine anxiolytic effects of lobeline (0.04 or 0.1 mg/kg), a nAChR antagonist, in C57BL/6J mice using elevated plus-maze (EPM) and marble-burying test. Lobeline (0.04 mg/kg) significantly increased open arm time on EPM… CONTINUE READING

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