Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes: role of the α subunit in agonist sensitivity and desensitization

@article{Gross1991NeuronalNA,
  title={Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes: role of the α subunit in agonist sensitivity and desensitization},
  author={Adrian Gross and Marc Ballivet and Duri Rungger and Daniel Bertrand},
  journal={Pfl{\"u}gers Archiv},
  year={1991},
  volume={419},
  pages={545-551}
}
Neuronal nicotinic acetylcholine receptors (nAChRs) were expressed in Xenopus laevis oocytes after nuclear injection of complementary deoxyribonucleic acid (cDNA) expression vectors. The two receptor subtypes α4/nα1 and α3/nα1 were readily distinguishable from one another by ACh sensitivity and desensitization. α3/nα1 receptors showed lower ACh sensitivity and stronger desensitization than α4/nα1 receptors. Furthermore, although the current/voltage relationship was very similar in both receptor… CONTINUE READING
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