Neuronal networks in vitro: formation and organization on biofunctionalized surfaces.

  title={Neuronal networks in vitro: formation and organization on biofunctionalized surfaces.},
  author={Christina L. Klein and Martin Scholl and Alfred Maelicke},
  journal={Journal of materials science. Materials in medicine},
  volume={10 12},
Receptor-mediated recognition of substrate molecules is a prerequisite for nerve cells in order to find their target structures in vivo and leads to formation of neuronal connections and networks. In order to study these mechanisms under in vitro conditions, we cultured embryonic hippocampal neurons or neuronal cell lines, SH-SY5Y and PCC7-PCC7-Mz1, onto biofunctionalized surfaces. Micropatterning on polymer surfaces, glass- and silicone-oxide-based chip materials was performed in a micrometer… CONTINUE READING


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