Neuronal localisation of neuropeptide Y gene expression in rat brain

@article{Morris1989NeuronalLO,
  title={Neuronal localisation of neuropeptide Y gene expression in rat brain},
  author={Brian J. Morris},
  journal={Journal of Comparative Neurology},
  year={1989},
  volume={290}
}
  • B. Morris
  • Published 1989
  • Biology, Medicine
  • Journal of Comparative Neurology
The cellular location of Neuropeptide Y (NPY) synthesis in rat brain is identified by using in‐situ hybridisation histochemistry. The results show that NPY mRNA is widely distributed through the rat brain, although the levels of NPY mRNA are surprisingly low. There is a large degree of variation in the content of NPY mRNA in different regions. The highest cellular levels of NPY mRNA are found in the arcuate nucleus of the hypothalamus, in the cerebral cortex, and in the hilar region of the… Expand
Cellular localization of neuropeptide Y mRNA and peptide in the brain of the Japanese quail and domestic chicken
TLDR
Site of NPY synthesis were localized in the brains of Japanese quail and domestic chickens by in situ hybridization histochemistry using a digoxigenin-labelled riboprobe, suggesting that NPY is synthesized and stored in these areas. Expand
Characterization of NPY mRNA-expressing cells in the human brain: co-localization with Y2 but not Y1 mRNA in the cerebral cortex, hippocampus, amygdala, and striatum
TLDR
A role for the Y2, but not Y1, as an autoreceptor in the NPY neuronal populations of the human brain is suggested. Expand
The distribution of neuropeptide Y gene expression in the chicken brain
TLDR
The distribution of cell groups expressing NPY mRNA was consistent with those regions exhibiting NPY immunoreactivity, and matches the distribution of receptor binding sites reported in the literature for the chicken brain, suggesting that NPY may be involved in functions controlled by these regions. Expand
Regulation of the Hypothalamo‐Pituitary Axis by Neuropeptide Y
  • J. Koenig
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
  • 1990
TLDR
Pharmacological and anatomical studies suggest that NPY is potentially capable of modulating ACTH secretion physiologically, especially during responses to stress when multiple factors are activated to insure a robust ACTH secretory response. Expand
Neuropeptide-Y gene expression in the goldfish brain: distribution and regulation by ovarian steroids.
TLDR
This report represents the first study on NPY gene expression in a nonmammalian species and demonstrates that 1) NPY mRNA is present in the neuroendocrine regulatory centers; and 2) ovarian steroids stimulate NPYGene expression in the POA. Expand
Regional Distribution of Putative NPY Y1 Receptors and Neurons Expressing Y1 mRNA in Forebrain Areas of the Rat Central Nervous System
TLDR
The present study further clarifies the anatomical distribution of multiple NPY binding sites within the central nervous system of the rat, and extends earlier suggestions that Y1 and Y2 receptor types are present within thecentral nervous system. Expand
Characterization of neuropeptide Y2 receptor protein expression in the mouse brain. I. Distribution in cell bodies and nerve terminals
TLDR
Y2R immunoreactivity was specific with its absence in Y2R knockout (KO) mice and in adjacent sections following preadsorption with the immunogenic peptide (10−5 M), and the widespread distribution of Y1, Y2, Y5, and y6 receptors suggests that NPY signaling through the Y2 R is common in the mouse brain. Expand
Neuropeptide Y Y1 receptors in the rat forebrain: autoradiographic demonstration of [125I][Leu31,Pro34]-NPY binding sites and neurons expressing Y1 receptor mRNA.
TLDR
The present study further enlightens the anatomical distribution of NPY binding sites of the Y1 type within the central nervous system of the rat, and extends the understanding of central actions ofNPY mediated via this type of receptor. Expand
Insulin is not a prerequisite for rapid regulation of neuropeptide Y gene transcription in the arcuate nucleus in food-restricted rats
TLDR
It is shown that NPY hnRNA levels also decreased rapidly after food consumption, suggesting that the postprandial increase in insulin release is not a prerequisite for the rapid downregulation of NPY gene transcription in the arcuate nucleus. Expand
Characterization of NPY Y2 receptor protein expression in the mouse brain. II. Coexistence with NPY, the Y1 receptor, and other neurotransmitter‐related molecules
TLDR
Examination of expression of the Y2 receptor (R) protein in the adult mouse brain and its association with NPY and the Y1R, as well as a range of additional neurotransmitters and signaling‐related molecules, provides further support that Y2R is mostly presynaptic, and thatY2Rs thus have a modulatory role in mediating presynptic neurotransmitter release. Expand
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