Neuronal injury in the infarct border: a neuropathological study in the rat

  title={Neuronal injury in the infarct border: a neuropathological study in the rat},
  author={Maiken Nedergaard},
  journal={Acta Neuropathologica},
Focal ischemia was induced in rats by occlusion of the middle cerebral artery (MCA). Infarction developed primarily in the basal ganglia. The development, density and distribution of neuronal injury in the cortex adjacent to the infarct were studied from 4 h to 1 year after occlusion of the artery. The brains were perfusion fixed, sub-serially sectioned, and stained with H + E, acid fuchsin/cresyl violet, and ad modum Klüver-Barrera. The number of injured neurons was assessed by direct visual… CONTINUE READING


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