Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways.

@article{Wen2008NeuronalII,
  title={Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways.},
  author={Ya-Dan Wen and Rui Sheng and Li-sha Zhang and Rong Han and Xuan Ya Zhang and Xing-Ding Zhang and Feng Han and Kohji Fukunaga and Zheng-Hong Qin},
  journal={Autophagy},
  year={2008},
  volume={4 6},
  pages={762-9}
}
It has been reported that ischemic insult increases the formation of autophagosomes and activates autophagy. However, the role of autophagy in ischemic neuronal damage remains elusive. This study was taken to assess the role of autophagy in ischemic brain damage. Focal cerebral ischemia was introduced by permanent middle cerebral artery occlusion (pMCAO). Activation of autophagy was assessed by morphological and biochemical examinations. To determine the contribution of autophagy/lysosome to… CONTINUE READING
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