Neuronal induction and regional identity by co-culture of adherent human embryonic stem cells with chicken notochords and somites.

@article{Salehi2011NeuronalIA,
  title={Neuronal induction and regional identity by co-culture of adherent human embryonic stem cells with chicken notochords and somites.},
  author={Hossein Salehi and Khadijeh Karbalaie and Shahnaz Razavi Razavi and Somaieh Tanhaee and Marziyh Nematollahi and Mohsen Sagha and Mohammad-Hossein Nasr-Esfahani and Hossein Baharvand},
  journal={The International journal of developmental biology},
  year={2011},
  volume={55 3},
  pages={
          321-6
        }
}
The role of somites and notochords in neuroectoderm differentiation from the embryonic ectoderm and its subsequent patterning into regional compartments along rostro-caudal and dorso-ventral axes, especially in humans, remains elusive. Here, we demonstrate the co-culture effect of somites and notochords isolated from chicken embryos on the neuronal differentiation and regional identity of an adherent culture of human embryonic stem cells (hESCs). Notochord increased the efficiency and speed of… CONTINUE READING

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