Neuronal histamine production remains unaltered in Parkinson's disease despite the accumulation of Lewy bodies and Lewy neurites in the tuberomamillary nucleus.

@article{Shan2012NeuronalHP,
  title={Neuronal histamine production remains unaltered in Parkinson's disease despite the accumulation of Lewy bodies and Lewy neurites in the tuberomamillary nucleus.},
  author={Ling Shan and Chun-qing Liu and Rawien A Balesar and Michel A. Hofman and Aimin Bao and Dick F. Swaab},
  journal={Neurobiology of aging},
  year={2012},
  volume={33 7},
  pages={1343-4}
}
Neuronal histamine production in the hypothalamic tuberomamillary nucleus (TMN) was hypothesized to change significantly in Parkinson's disease (PD) in relation to the accumulation of Lewy bodies/Lewy neurites (LBs/LNs). We measured the messenger ribonucleic acid (mRNA) levels of histidine decarboxylase (HDC), the key enzyme of histamine production, and the amount of LBs/LNs in the TMN by quantitative in situ hybridization and immunocytochemistry in postmortem human brain material of clinical… CONTINUE READING

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