Neuronal growth cone collapse and inhibition of protein fatty acylation by nitric oxide

@article{Hess1993NeuronalGC,
  title={Neuronal growth cone collapse and inhibition of protein fatty acylation by nitric oxide},
  author={Douglas T. Hess and Sean I. Patterson and Deanna S Smith and J. H. Pate Skene},
  journal={Nature},
  year={1993},
  volume={366},
  pages={562-565}
}
NITRIC oxide, a free-radical gas produced endogenously by several mammalian cell types1–6, has been implicated as a diffusible inter-cellular messenger subserving use-dependent modification of synaptic efficacy in the mature central nervous system7–10. It has been suggested on theoretical grounds that nitric oxide might play an analogous role during the establishment of ordered connections by developing neurons11. We report here that nitric oxide rapidly and reversibly inhibits growth of… CONTINUE READING

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