Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse

@article{Aoyama2006NeuronalGD,
  title={Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse},
  author={Koji Aoyama and Sang Won Suh and Aaron M Hamby and Jialing Liu and Wai Yee Chan and Yongmei Chen and Raymond A Swanson},
  journal={Nature Neuroscience},
  year={2006},
  volume={9},
  pages={119-126}
}
Uptake of the neurotransmitter glutamate is effected primarily by transporters expressed on astrocytes, and downregulation of these transporters leads to seizures and neuronal death. Neurons also express a glutamate transporter, termed excitatory amino acid carrier–1 (EAAC1), but the physiological function of this transporter remains uncertain. Here we report that genetically EAAC1-null (Slc1a1−/−) mice have reduced neuronal glutathione levels and, with aging, develop brain atrophy and… CONTINUE READING
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