Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse

  title={Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse},
  author={Koji Aoyama and S. W. Suh and Aaron M Hamby and J. Liu and W. Y. Chan and Y. Chen and R. Swanson},
  journal={Nature Neuroscience},
  • Koji Aoyama, S. W. Suh, +4 authors R. Swanson
  • Published 2006
  • Biology, Medicine
  • Nature Neuroscience
  • Uptake of the neurotransmitter glutamate is effected primarily by transporters expressed on astrocytes, and downregulation of these transporters leads to seizures and neuronal death. Neurons also express a glutamate transporter, termed excitatory amino acid carrier–1 (EAAC1), but the physiological function of this transporter remains uncertain. Here we report that genetically EAAC1-null (Slc1a1−/−) mice have reduced neuronal glutathione levels and, with aging, develop brain atrophy and… CONTINUE READING
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