Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations

@article{Plummer2005NeuronalEO,
  title={Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations},
  author={Nicholas W. Plummer and Teresa L. Squire and Sudha Srinivasan and Elizabeth Huang and Jon S. Zawistowski and Hiroaki Matsunami and Laura P. Hale and Douglas A. Marchuk},
  journal={Mammalian Genome},
  year={2005},
  volume={17},
  pages={119-128}
}
Cerebral cavernous malformations are vascular defects of the central nervous system consisting of clusters of dilated vessels that are subject to frequent hemorrhaging. The genes mutated in three forms of autosomal dominant cerebral cavernous malformations have been cloned, but it remains unclear which cell type is ultimately responsible for the lesion. In this article we describe mice with a gene trap insertion in the Ccm2 gene. Consistent with the human phenotype, heterozygous animals develop… CONTINUE READING