Neuronal expression and regulation of CGRP promoter activity following viral gene transfer into cultured trigeminal ganglia neurons

@article{Durham2004NeuronalEA,
  title={Neuronal expression and regulation of CGRP promoter activity following viral gene transfer into cultured trigeminal ganglia neurons},
  author={Paul L. Durham and Penny X. Dong and Kevin T. Belasco and Jeffrey Kasperski and Andrew F Russo},
  journal={Brain Research},
  year={2004},
  volume={997},
  pages={103-110}
}
We have examined the regulation of calcitonin gene-related peptide (CGRP) promoter activity in primary cultures of rat trigeminal ganglia neurons. A viral vector was used to circumvent the potential complication of examining only a small subpopulation of cells in the heterogeneous cultures. Infection with high titers of recombinant adenovirus containing 1.25 kb of the rat CGRP promoter linked to the beta-galactosidase reporter gene (AdCGRP-lacZ) yielded expression in about 50% of the CGRP… CONTINUE READING
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