Neuronal ensemble control of prosthetic devices by a human with tetraplegia

@article{Hochberg2006NeuronalEC,
  title={Neuronal ensemble control of prosthetic devices by a human with tetraplegia},
  author={Leigh R. Hochberg and Mijail D. Serruya and Gerhard Friehs and Jon A. Mukand and Maryam Saleh and Abraham H. Caplan and Almut Branner and David Chen and Richard D. Penn and John P. Donoghue},
  journal={Nature},
  year={2006},
  volume={442},
  pages={164-171}
}
Neuromotor prostheses (NMPs) aim to replace or restore lost motor functions in paralysed humans by routeing movement-related signals from the brain, around damaged parts of the nervous system, to external effectors. To translate preclinical results from intact animals to a clinically useful NMP, movement signals must persist in cortex after spinal cord injury and be engaged by movement intent when sensory inputs and limb movement are long absent. Furthermore, NMPs would require that intention… 
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