Neuronal dysfunction and death in rabies virus infection

  title={Neuronal dysfunction and death in rabies virus infection},
  author={Zhen Fu and Alan C Jackson},
  journal={Journal of NeuroVirology},
Because morphologic changes in natural rabies are usually relatively mild, it is thought that the severe clinical disease with a fatal outcome must be due to neuronal dysfunction of rabies virus-infected neurons. The precise bases of this functional impairment are unknown, and current knowledge on electrophysiological alterations, effects on ion channels and neurotransmission, and neurotoxicity are reviewed. Rabies virus may induce neuronal death, possibly through apoptotic mechanisms. Neuronal… CONTINUE READING