Neuronal-driven angiogenesis: role of NGF in retinal neovascularization in an oxygen-induced retinopathy model.

@article{Liu2010NeuronaldrivenAR,
  title={Neuronal-driven angiogenesis: role of NGF in retinal neovascularization in an oxygen-induced retinopathy model.},
  author={Xialin Liu and Ding-ding Wang and Yizhi Liu and Yan Luo and Wei Ma and Wei Xiao and Qiang Yu},
  journal={Investigative ophthalmology \& visual science},
  year={2010},
  volume={51 7},
  pages={
          3749-57
        }
}
PURPOSE. To evaluate the role of nerve growth factor (NGF) in retinal neovascularization in an oxygen-induced retinopathy (OIR) model. METHODS. The OIR model was established in C57BL/6J mice. NGF mRNA expression in retina was measured by quantitative real-time PCR. NGF expression in protein levels was evaluated by ELISA and immunostaining with NGF antibody. The effects of NGF on retinal neovascularization were evaluated by intravitreal injections of exogenous NGF and TrkA receptor inhibitor… 
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TLDR
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Evidence is provided that proNGF can contribute to PDR at least in part via activation of TrkA through activation of p75NTR receptors.
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