Neuronal differentiation of human neuroblastoma SH-SY5Y cells by gangliosides


Exogenous administration of gangliosides induced neuronal differentiation with prominent neuritogenesis in human neuroblastoma SH-SY5Y cells in vitro. Neuritogenesis was characterized by ruffling of the cell membrane, the development of lamellipodia and filopodia, and the subsequent elongation and branching of the neurites ultrastructurally. Both axons and… (More)
DOI: 10.1007/BF02478862

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