Neuronal differentiation involves a shift from glucose oxidation to fermentation.

@article{Fornazari2011NeuronalDI,
  title={Neuronal differentiation involves a shift from glucose oxidation to fermentation.},
  author={Maynara Fornazari and Isis Cristina do Nascimento and Arthur Andrade Nery and Camille C Caldeira da Silva and Alicia J Kowaltowski and Henning Ulrich},
  journal={Journal of bioenergetics and biomembranes},
  year={2011},
  volume={43 5},
  pages={531-9}
}
Energy metabolism in the adult brain consumes large quantities of glucose, but little is known to date regarding how glucose metabolism changes during neuronal differentiation, a process that is highly demanding energetically. We studied changes in glucose metabolism during neuronal differentiation of P19 mouse embryonal carcinoma cells, E14Tg2A embryonic stem cells as well as during brain development of BLC57 mice. In all these models, we find that neurogenesis is accompanied by a shift from… CONTINUE READING