Neuronal depolarization enhances the transcription of the neuronal serine protease inhibitor neuroserpin.

@article{Berger1999NeuronalDE,
  title={Neuronal depolarization enhances the transcription of the neuronal serine protease inhibitor neuroserpin.},
  author={Philipp Berger and Serguei Kozlov and Paolo Cinelli and Stefan R Krueger and Lorenz Vogt and Peter Sonderegger},
  journal={Molecular and cellular neurosciences},
  year={1999},
  volume={14 6},
  pages={455-67}
}
Neuroserpin is an axonally secreted neuronal serine protease inhibitor. Based on its inhibitory activity towards tissue plasminogen activator (tPA) and its predominant expression in the cerebral cortex, the hippocampus, and the amygdala, a role for neuroserpin in the regulation of neural plasticity has been suggested. We recently found that neuroserpin mRNA is increased in cultured hippocampal neurons upon depolarization with elevated extracellular KCl. Using luciferase reporter constructs… CONTINUE READING
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