Neuronal density determines network connectivity and spontaneous activity in cultured hippocampus.

  title={Neuronal density determines network connectivity and spontaneous activity in cultured hippocampus.},
  author={Miriam Ivenshitz and Menahem Segal},
  journal={Journal of neurophysiology},
  volume={104 2},
The effects of neuronal density on morphological and functional attributes of the evolving networks were studied in cultured dissociated hippocampal neurons. Plating at different densities affected connectivity among the neurons, such that sparse networks exhibited stronger synaptic connections between pairs of recorded neurons. This was associated with different patterns of spontaneous network activity with enhanced burst size but reduced burst frequency in the sparse cultures. Neuronal… 

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