Neuronal death in nigral grafts in the absence of poly (ADP-ribose) polymerase activation.

@article{Schierle1999NeuronalDI,
  title={Neuronal death in nigral grafts in the absence of poly (ADP-ribose) polymerase activation.},
  author={Gabriele S. Kaminski Schierle and Oskar Hansson and Elisa Ferrando-May and Pierluigi Nicotera and Patrik Brundin and Marcel Leist},
  journal={Neuroreport},
  year={1999},
  volume={10 16},
  pages={3347-51}
}
The exact causes of the extensive cell death in nigral transplants are still unknown. Since poly-(ADP-ribose) polymerase (PARP) overactivation has been implicated in neuronal death, we examined the effects of PARP on the survival of nigral grafts by using donor tissue from PARP knock-out or wild-type mice. Eight hours after preparation of the nigral cell suspension, cell damage was quantified by measurement of lactate dehydrogenase release, DNA fragmentation and caspase activation. At this… CONTINUE READING