Neuronal death in newborn striatum after hypoxia-ischemia is necrosis and evolves with oxidative stress.

@article{Martin2000NeuronalDI,
  title={Neuronal death in newborn striatum after hypoxia-ischemia is necrosis and evolves with oxidative stress.},
  author={Lee J. Martin and Ansgar Maria Brambrink and Ann C. Price and Andrew P Kaiser and Dawn Mueller Agnew and Rebecca N. Ichord and Richard J. Traystman},
  journal={Neurobiology of disease},
  year={2000},
  volume={7 3},
  pages={169-91}
}
The mechanisms for neurodegeneration after hypoxia-ischemia (HI) in newborns are not understood. We tested the hypothesis that striatal neuron death is necrosis and evolves with oxidative stress and selective organelle damage. Piglets ( approximately 1 week old) were used in a model of hypoxia-asphyxia and survived for 3, 6, 12, or 24 h. Neuronal death was progressive over 3-24 h recovery, with approximately 80% of putaminal neurons dead at 24 h. Striatal DNA was digested randomly at 6-12 h… CONTINUE READING
36 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

Similar Papers

Loading similar papers…