Neuronal cytoskeletal alterations evoked by a platelet-activating factor (PAF) analogue.

  title={Neuronal cytoskeletal alterations evoked by a platelet-activating factor (PAF) analogue.},
  author={Robert S. McNeil and John W. Swann and Bill R. Brinkley and Gary D. Clark},
  journal={Cell motility and the cytoskeleton},
  volume={43 2},
Platelet-activating factor (PAF), a phospholipid signaling molecule found in brain, modulates several neural functions and is implicated in the human developmental brain disorder Miller-Dieker Lissencephaly (MDL). Exposure to PAF, and a non-hydrolyzable analogue, methyl carbamyl PAF (mc-PAF), produces the following rapid, reversible effects upon cultured hippocampal neurites: growth cone collapse, neurite retraction, and neurite varicosity formation. In this study, the cytoskeletal alterations… CONTINUE READING
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