Neuronal control of leech behavior

@article{Kristan2005NeuronalCO,
  title={Neuronal control of leech behavior},
  author={W. Kristan and R. Calabrese and W. O. Friesen},
  journal={Progress in Neurobiology},
  year={2005},
  volume={76},
  pages={279-327}
}
The medicinal leech has served as an important experimental preparation for neuroscience research since the late 19th century. Initial anatomical and developmental studies dating back more than 100 years ago were followed by behavioral and electrophysiological investigations in the first half of the 20th century. More recently, intense studies of the neuronal mechanisms underlying leech movements have resulted in detailed descriptions of six behaviors described in this review; namely, heartbeat… Expand
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References

SHOWING 1-10 OF 390 REFERENCES
Identified neurons and leech swimming behavior
TLDR
The observation that constant input can result in variable motor output suggests that, in addition to describing a cell's identity in terms of structure and function, factors such as behavioral context and the "internal state" of the nervous system must also be considered. Expand
Development of spontaneous and evoked behaviors in the medicinal leech
TLDR
The order in which behaviors arise during the period of embryonic development is investigated and the time at which each behavior is first expressed is determined, finding that in response to stimulation of the midbody, young embryos produced a behavior called “circumferential indentation,” whereas older embryos produced local bending, a response previously described for adults. Expand
Neuronal control of leech swimming.
TLDR
The pathway by which body wall stimulation initiates swimming shows a simple form of learning, that is habituation, and the biogenic amine serotonin, which is found in the nerve cord, affects leech swimming in a number of ways. Expand
Serotonin in the leech central nervous system: anatomical correlates and behavioral effects
TLDR
Morphometric analyses indicated that ganglionic levels of serotonin correlated primarily with longitudinal variations in the number of serotonin neurons per ganglion and secondarily with volume of the Retzius cells, both of which are largest in mid-body domains. Expand
The neurobiology of swimming in the leech
TLDR
The special promise of the leech, because of the relative simplicity of its nervous system even among invertebrates, is that any behavior can be completely characterized; i.e. the contribution of every neuron in a behaviors can be evaluated. Expand
Modulation of swimming behavior in the medicinal leech
TLDR
It is proposed that alterations in synaptic interactions resulting from exposure to elevated serotonin levels, coupled with the changes in MN cellular properties described earlier, are crucial to the increased efficacy of MNs in participating in generating and expressing the leech swimming rhythm. Expand
A cephalic projection neuron involved in locomotion is dye coupled to the dopaminergic neural network in the medicinal leech
TLDR
It is demonstrated that Tr2 is dye coupled to the dopaminergic neural network distributed in the head brain, and it is determined that bath application of DA to the brain and entire nerve cord reliably and rapidly terminates swimming in all preparations exhibiting fictive swimming. Expand
The neural control of alternate heartbeat coordination states in the leech,Hirudo medicinalis
TLDR
A more complete heart control circuit diagram is now available that accounts for the observed activity cycles of the various HN and HE cells and consequently for the behavior of the hearts themselves. Expand
Physiological and morphological analysis of synaptic transmission between leech motor neurons
TLDR
Three different methods were used to demonstrate that synaptic transmission remained in the absence of impulses in the inhibitory motor neurons, and it is proposed that these inhibitory connections between motor neurons are probably monosynaptic. Expand
Serotonin integrates the feeding behavior of the medicinal leech
TLDR
Serotonin is localized to a limited population of identifiable neurons in the C.N.S., and plays a pivotal and mandatory role in organizing the feeding behavior of the medicinal leech. Expand
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