Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions.

@article{Miranda1993NeuronalCO,
  title={Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions.},
  author={Rajesh C. Miranda and Farida Sohrabji and C. Dominique Toran-Allerand},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 14},
  pages={6439-43}
}
Development and survival of neurons in the central nervous system are dependent on the activity of a variety of endogenous neurotrophic agents. Using combined isotopic and nonisotopic in situ hybridization histochemistry, we have found that subsets of neurons within the developing forebrain coexpress the mRNAs for both neurotrophins (nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3) and their receptors (p75NGFR, TrkA, and TrkB). The colocalization of mRNA for… CONTINUE READING
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