Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins.

  title={Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins.},
  author={Veena Prahlad and Richard I. Morimoto},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 34},
The consequence of chronic protein misfolding is the basis of many human diseases. To combat the deleterious effects of accumulated protein damage, all cells possess robust quality-control systems, specifically molecular chaperones and clearance machineries, that sense and respond to protein misfolding. However, for many protein conformational diseases, it is unclear why this quality-control system does not efficiently counter protein aggregation. Previous findings that the heat shock response… CONTINUE READING
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