Neuronal chromatin dynamics of imprinting in development and disease.

  title={Neuronal chromatin dynamics of imprinting in development and disease.},
  author={Karen N. Leung and Stormy J Chamberlain and Marc E. Lalande and Janine M LaSalle},
  journal={Journal of cellular biochemistry},
  volume={112 2},
Epigenetic mechanisms play essential roles in mammalian neurodevelopment and genetic mutations or chromosomal deletions or duplications of epigenetically regulated loci or pathways result in several important human neurodevelopmental disorders. Postnatal mammalian neurons have among the most structured and dynamic nuclear organization of any cell type. Human chromosome 15q11-13 is an imprinted locus required for normal neurodevelopment and is regulated by a plethora of epigenetic mechanisms in… CONTINUE READING