Neuronal ceroid lipofuscinosis in Devon cattle is caused by a single base duplication (c.662dupG) in the bovine CLN5 gene.

@article{Houweling2006NeuronalCL,
  title={Neuronal ceroid lipofuscinosis in Devon cattle is caused by a single base duplication (c.662dupG) in the bovine CLN5 gene.},
  author={Peter J Houweling and Julie A. L. Cavanagh and David N Palmer and Tony Frugier and Nadia Lesley Mitchell and Peter Windsor and Herman W. Raadsma and Imke Tammen},
  journal={Biochimica et biophysica acta},
  year={2006},
  volume={1762 10},
  pages={
          890-7
        }
}
The neuronal ceroid lipofuscinoses (NCLs, Batten disease) are recessively inherited neurodegenerative disorders that affect humans and other animals, characterised by brain atrophy and the accumulation of lysosome derived fluorescent storage bodies in neurons and most other cells. Common clinical signs include blindness, ataxia, dementia, seizures and premature death. The associated genes for six different human forms have been identified (CLN1, CLN2, CLN3, CLN5, CLN6 and CLN8), and three other… CONTINUE READING
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